کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2072156 1078876 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymer–drug conjugates: Origins, progress to date and future directions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Polymer–drug conjugates: Origins, progress to date and future directions
چکیده انگلیسی

This overview focuses on bioconjugates of water-soluble polymers with low molecular weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the-art is reviewed. Then research directions needed for the acceleration of the translation of nanomedicines into the clinic are outlined. Two most important directions, synthesis of backbone degradable polymer carriers and drug-free macromolecular therapeutics, a new paradigm in drug delivery, are discussed in detail. Finally, the future perspectives of the field are briefly discussed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 65, Issue 1, January 2013, Pages 49–59
نویسندگان
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