کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2072377 1078958 2006 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thermo- and pH-responsive polymers in drug delivery
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Thermo- and pH-responsive polymers in drug delivery
چکیده انگلیسی

Stimuli-responsive polymers show a sharp change in properties upon a small or modest change in environmental condition, e.g. temperature, light, salt concentration or pH. This behaviour can be utilised for the preparation of so-called ‘smart’ drug delivery systems, which mimic biological response behaviour to a certain extent. The possible environmental conditions to use for this purpose are limited due to the biomedical setting of drug delivery as application. Different organs, tissues and cellular compartments may have large differences in pH, which makes the pH a suitable stimulus. Therefore the majority of examples, discussed in this paper, deal with pH-responsive drug delivery system. Thermo-responsive polymer is also covered to a large extent, as well as double-responsive system. The physico-chemical behaviour underlying the phase transition will be discussed in brief. Then selected examples of applications are described.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 58, Issue 15, 30 December 2006, Pages 1655–1670
نویسندگان
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