Role of cancer stem cells in brain tumors

Cancer stem cells contribute to tumor progression, resulting in their capacity to persistently self-renew and propagate tumors. Recent evidence suggests that brain cancer stem cells (BCSCs) are critical for tumor vascular development and therapeutic resistance. Here, we outline the crucial molecular mechanisms and interacting niches involved in BCSCs, which uncovering multiple potential targets for malignant brain tumors and may provide clues for developing novel antibrain tumor treatments.