کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2076202 1544993 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimal parameter settings for information processing in gene regulatory networks
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
پیش نمایش صفحه اول مقاله
Optimal parameter settings for information processing in gene regulatory networks
چکیده انگلیسی
Gene networks can often be interpreted as computational circuits. This article investigates the computational properties of gene regulatory networks defined in terms of the speed and the accuracy of the output of a gene network. It will be shown that there is no single optimal set of parameters, but instead, there is a trade-off between speed and accuracy. Using the trade-off it will also be shown how systems with various parameters can be ranked with respect to their computational efficiency. Numerical analysis suggests that the trade-off can be improved when the output gene is repressing itself, even though the accuracy or the speed of the auto-regulated system may be worse than the unregulated system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 104, Issues 2–3, May–June 2011, Pages 99-108
نویسندگان
, , ,