کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2076272 1079433 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emergence of robust regulatory motifs from in silico evolution of sustained oscillation
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
پیش نمایش صفحه اول مقاله
Emergence of robust regulatory motifs from in silico evolution of sustained oscillation
چکیده انگلیسی

The relationship between robustness and evolvability (easiness to evolve), and the evolutionary emergence of robust genetic circuits in biology have attracted much attention in systems biology. This paper investigates in silico the influence of the cis-regulation logic and the coupling of feedback loops on the evolvability and robustness of gene regulatory motifs that can generate sustained oscillation. Our simulation results indicate that both evolvability and robustness of the considered regulatory motifs depend on the cis-regulation logic and the way in which positive and negative feedback loops are coupled. Most interestingly, our findings suggest that robust regulatory motifs can emerge from evolution without an explicit selection pressure on robustness and adding noise in the parameters during the evolution is likely to promote the evolution of sustained oscillation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 103, Issue 1, January 2011, Pages 38–44
نویسندگان
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