کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2076694 1079460 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Automatic reconstruction of molecular and genetic networks from discrete time series data
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
پیش نمایش صفحه اول مقاله
Automatic reconstruction of molecular and genetic networks from discrete time series data
چکیده انگلیسی

We apply a mathematical algorithm which processes discrete time series data to generate a complete list of Petri net structures containing the minimal number of nodes required to reproduce the data set. The completeness of the list as guaranteed by a mathematical proof allows to define a minimal set of experiments required to discriminate between alternative network structures. This in principle allows to prove all possible minimal network structures by disproving all alternative candidate structures. The dynamic behaviour of the networks in terms of a switching rule for the transitions of the Petri net is part of the result. In addition to network reconstruction, the algorithm can be used to determine how many yet undetected components at least must be involved in a certain process. The algorithm also reveals all alternative structural modifications of a network that are required to generate a predefined behaviour.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 93, Issue 3, September 2008, Pages 181–190
نویسندگان
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