کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2076771 1544997 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formation and maintenance of tubular membrane projections: Experiments and numerical calculations
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
پیش نمایش صفحه اول مقاله
Formation and maintenance of tubular membrane projections: Experiments and numerical calculations
چکیده انگلیسی

To study the mechanical properties of lipid membranes, we manipulated liposomes by using a system comprising polystyrene beads and laser tweezers, and measured the force required to transform their shapes. When two beads pushed the membrane from inside, spherical liposomes transformed into a lemon-shape. Then a discontinuous shape transformation occurred to form a membrane tube from either end of the liposomes, and the force dropped drastically. We analyzed these processes using a mathematical model based on the bending elasticity of the membranes. Numerical calculations showed that when the bead size was taken into account, the model reproduced both the liposomal shape transformation and the force–extension relation. This result suggests that the size of the beads is responsible for the existence of a force barrier for the tube formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 93, Issues 1–2, July–August 2008, Pages 115–119
نویسندگان
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