کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2077635 1079732 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Primary Tumor Genotype Is an Important Determinant in Identification of Lung Cancer Propagating Cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Primary Tumor Genotype Is an Important Determinant in Identification of Lung Cancer Propagating Cells
چکیده انگلیسی

SummarySuccessful cancer therapy requires the elimination or incapacitation of all tumor cells capable of regenerating a tumor. Therapeutic advances therefore necessitate the characterization of the cells that are able to propagate a tumor in vivo. We show an important link between tumor genotype and isolation of tumor-propagating cells (TPCs). Three mouse models of the most common form of human lung cancer each had TPCs with a unique cell-surface phenotype. The cell-surface marker Sca1 did not enrich for TPCs in tumors initiated with oncogenic Kras, and only Sca1-negative cells propagated EGFR mutant tumors. In contrast, Sca1-positive cells were enriched for tumor-propagating activity in Kras tumors with p53 deficiency. Primary tumors that differ in genotype at just one locus can therefore have tumor-propagating cell populations with distinct markers. Our studies show that the genotype of tumor samples must be considered in studies to identify, characterize, and target tumor-propagating cells.

Graphical AbstractFigure optionsDownload high-quality image (309 K)Download as PowerPoint slideHighlights
► Identification of the first lung tumor-propagating cell population
► Lung cancers of different genotype have tumor-propagating cells with distinct markers
► Tumor samples should be separated by genotype to study tumor-propagating cells

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 7, Issue 1, 2 July 2010, Pages 127–133
نویسندگان
, , , , , , , , , ,