کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2077677 | 1079737 | 2010 | 13 صفحه PDF | دانلود رایگان |
SummaryRecent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26+ cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26+ cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26+ cells, but not CD26− cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26+ cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy.
► Metastatic colorectal cancers contain a subset of CD26+ cancer stem cells
► Nonmetastatic tumors with CD26+ CSCs frequently proceed to metastasis
► Isolated CD26+ CSCs can initiate distant metastasis in a mouse model
► CD26+ CSCs show enhanced invasiveness and migratory potential
Journal: - Volume 6, Issue 6, 4 June 2010, Pages 603–615