کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2078292 1079781 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells
چکیده انگلیسی

SummaryIn the hematopoietic system, Notch signaling specifies T cell lineage fate, in part through negative regulation of B cell and myeloid lineage development. However, we unexpectedly observed the development of megakaryocytes when using heterotypic cocultures of hematopoietic stem cells with OP9 cells expressing Delta-like1, but not with parental OP9 cells. This effect was abrogated by inhibition of Notch signaling either with γ-secretase inhibitors or by expression of the dominant-negative Mastermind-like1. The importance of Notch signaling for megakaryopoietic development in vivo was confirmed by using mutant alleles that either activate or inhibit Notch signaling. These findings indicate that Notch is a positive regulator of megakaryopoiesis and plays a more complex role in cell-fate decisions among myeloid progenitors than previously appreciated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 3, Issue 3, 11 September 2008, Pages 314–326
نویسندگان
, , , , , , , , ,