کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2078396 1079787 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
چکیده انگلیسی

SummaryIt is widely postulated that tissue aging could be, at least partially, caused by reduction of stem cell number, activity, or both. However, the mechanisms of controlling stem cell aging remain largely a mystery. Here, we use Drosophila ovarian germline stem cells (GSCs) as a model to demonstrate that age-dependent decline in the functions of stem cells and their niche contributes to overall stem cell aging. BMP signaling activity from the niche significantly decreases with age, and increasing BMP signaling can prolong GSC life span and promote their proliferation. In addition, the age-dependent E-cadherin decline in the stem cell-niche junction also contributes to stem cell aging. Finally, overexpression of SOD, an enzyme that helps eliminate free oxygen species, in either GSCs or their niche alone can prolong GSC life span and increase GSC proliferation. Therefore, this study demonstrates that stem cell aging is controlled extrinsically and intrinsically in the Drosophila ovary.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 1, Issue 4, 11 October 2007, Pages 458–469
نویسندگان
, , , , , , , ,