کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2078429 1401223 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular Obstacles to Clinical Translation of iPSCs
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Molecular Obstacles to Clinical Translation of iPSCs
چکیده انگلیسی

The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) using defined factors provides new tools for biomedical research. However, some iPSC clones display tumorigenic and immunogenic potential, thus raising concerns about their utility and safety in the clinical setting. Furthermore, variability in iPSC differentiation potential has also been described. Here we discuss whether these therapeutic obstacles are specific to transcription-factor-mediated reprogramming or inherent to every cellular reprogramming method. Finally, we address whether a better understanding of the mechanism underlying the reprogramming process might improve the fidelity of reprogramming and, therefore, the iPSC quality.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 19, Issue 3, 1 September 2016, Pages 298–309
نویسندگان
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