کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2078860 | 1545049 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Taxol Determination from Pestalotiopsis pauciseta, a Fungal Endophyte of a Medicinal Plant
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Taxol Determination from Pestalotiopsis pauciseta, a Fungal Endophyte of a Medicinal Plant Taxol Determination from Pestalotiopsis pauciseta, a Fungal Endophyte of a Medicinal Plant](/preview/png/2078860.png)
چکیده انگلیسی
Taxol is the most effective antitumor agent developed in the past three decades. It has been used for the effective treatment of a variety of cancers. A taxol-producing endophytic fungus Pestalotiopsis pauciseta (strain CHP-11) was isolated from the leaves of Cardiospermum helicacabum and screened for taxol production. The fungus was identified based on the morphology of the fungal culture and the characteristics of the spores, and screened for taxol production. The amount of taxol produced by this endophytic fungus was 113.3 μg/L, which was quantified by HPLC. Thus, the fungus can serve as a potential material for fungus engineering to improve taxol production. This fungal taxol also had strong anticancer activity against some cancer cells viz., BT 220, H116, Int 407, HL 251, and HLK 210 tested by Apoptotic assay, and it is indicated that with the increase of taxol concentration from 0.005-0.05 M, the taxol induced increased cell death through apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Biotechnology - Volume 24, Issue 8, August 2008, Pages 1433-1438
Journal: Chinese Journal of Biotechnology - Volume 24, Issue 8, August 2008, Pages 1433-1438
نویسندگان
V Gangadevi, M Murugan, J Muthumary,