کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2079309 1079859 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
METABOLIC ENGINEERING OF BIOCATALYSTS FOR CARBOXYLIC ACIDS PRODUCTION
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
METABOLIC ENGINEERING OF BIOCATALYSTS FOR CARBOXYLIC ACIDS PRODUCTION
چکیده انگلیسی

Fermentation of renewable feedstocks by microbes to produce sustainable fuels and chemicals has the potential to replace petrochemical-based production. For example, carboxylic acids produced by microbial fermentation can be used to generate primary building blocks of industrial chemicals by either enzymatic or chemical catalysis. In order to achieve the titer, yield and productivity values required for economically viable processes, the carboxylic acid-producing microbes need to be robust and well-performing. Traditional strain development methods based on mutagenesis have proven useful in the selection of desirable microbial behavior, such as robustness and carboxylic acid production. On the other hand, rationally-based metabolic engineering, like genetic manipulation for pathway design, has becoming increasingly important to this field and has been used for the production of several organic acids, such as succinic acid, malic acid and lactic acid. This review investigates recent works on Saccharomyces cerevisiae and Escherichia coli, as well as the strategies to improve tolerance towards these chemicals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational and Structural Biotechnology Journal - Volume 3, Issue 4, October 2012, Pages 1–9
نویسندگان
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