Metabolome responses to physiological and nutritional challenges

• Current pathologies are drawn by simultaneous homeostatic perturbations.
• Challenge tests allow to gain knowledge of the ability to counteract organism perturbations.
• Foodomic tools report us changes in metabolomic profiles with an holistic view.
• Metabolome profiling provides phenotypic readouts and can identify new biomarkers.

Nutrition-related pathologies need a broader nutritional view to address the multitude of involved homeostatic perturbations. Nutrition challenge tests combined with non-targeted metabolomics, as a scientific methodology to obtain new information on the dietary components, will accelerate the discovery of new biomarkers, thus preventing diet-related pathways in early disease stages or in healthy individuals.