کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2079811 1401249 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of cell therapy medicinal products by academic institutes
ترجمه فارسی عنوان
توسعه داروهای سلولی درمانی توسط موسسات دانشگاهی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• Strengths and hurdles associated with academic development of cell therapies.
• Reasons promising cell therapies fail to reach late-stage development.
• Recommendations to stakeholders involved in cell therapy development are provided.

In the rapidly evolving fields of cellular immunotherapy, gene therapy and regenerative medicine, a wide range of promising cell therapy medicinal products are in clinical development. Most products originate from academic research and are explored in early exploratory clinical trials. However, the success rate toward approval for regular patient care is disappointingly low. In this paper, we define strengths and hurdles applying to the development of cell therapy medicinal products in academic institutes, and analyze why only a few promising cell therapies have reached late-stage clinical development. Subsequently, we provide recommendations to stakeholders involved in development of cell therapies to exploit their potential clinical benefit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 8, August 2016, Pages 1206–1212
نویسندگان
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