کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2079821 1401249 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting delivery in Parkinson's disease
ترجمه فارسی عنوان
تحویل هدف در بیماری پارکینسون
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• Neuroprotective therapies remain an unmet need for Parkinson's disease.
• Targeting may allow delivery of neuroprotective molecules to the diseased brain.
• This has many challenges and opportunities for the therapy of Parkinson's disease.

Disease-modifying therapies for Parkinson's disease (PD), with the potential to halt the neurodegenerative process and to stimulate the protection, repair, and regeneration of dopaminergic neurons, remain a vital but unmet clinical need. Targeting the delivery of current and new therapeutics directly to the diseased brain region (in particular the nigrostriatal pathway) could result in greater improvements in the motor functions that characterise PD. Here, we highlight some of the opportunities and challenges facing the development of the next generation of therapies for patients with PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 8, August 2016, Pages 1313–1320
نویسندگان
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