کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2079822 | 1401249 | 2016 | 9 صفحه PDF | دانلود رایگان |
• Many anticancer compounds are unable to demonstrate pharmacological activity because they do not reach therapeutic concentration at the site of action.
• Nanotechnology is a useful tool to improve the selective delivery of anticancer compounds to their site of action.
• An interesting application of anticancer nanotechnology is represented by nanostructures spontaneously obtained by self-assembly of drug conjugates linked to a proper chemical entity.
• The generation of hetero-NPs could be exploited for personalized combined treatment of different types of diseases.
Self-assembly drug conjugate preparation is a promising approach to improve activity and penetration through physiological barriers of potent small molecules, as well as to reduce any side effects. Drug conjugates can self-assemble in water to form nanoparticles (NPs) that offer several advantages because: (i) they are easy to obtain; (ii) they can reach high local drug concentration in tumor tissues; and (iii) they can reduce the side effects of drugs. All these factors improve drug pharmacokinetic properties. Here, we have reviewed the scope of nanotechnology-based self-assembly drug delivery approaches focusing on prodrugs able to form NPs by self-assembly; we have also summarized the current perspective and challenges facing the successful treatment of cancer.
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Journal: Drug Discovery Today - Volume 21, Issue 8, August 2016, Pages 1321–1329