کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2079839 1079896 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drugs affecting glycosaminoglycan metabolism
ترجمه فارسی عنوان
داروهای مؤثر بر متابولیسم گلیکوزامینوگلیکان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• A classification of drugs affecting glycosaminoglycan (GAG) metabolism is provided.
• Rationally designed small molecule drugs display in vivo efficacy.
• A number of clinically approved drugs affect GAG metabolism.
• Strategies are proposed for the discovery of drugs specifically affecting GAGs.

Glycosaminoglycans (GAGs) are charged polysaccharides ubiquitously present at the cell surface and in the extracellular matrix. GAGs are crucial for cellular homeostasis, and their metabolism is altered during pathological processes. However, little consideration has been given to the regulation of the GAG milieu through pharmacological interventions. In this review, we provide a classification of small molecules affecting GAG metabolism based on their mechanism of action. Furthermore, we present evidence to show that clinically approved drugs affect GAG metabolism and that this could contribute to their therapeutic benefit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 7, July 2016, Pages 1162–1169
نویسندگان
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