کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2079891 1079901 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Applying lessons learned from cytomegalovirus infection in transplant patients to vaccine design
ترجمه فارسی عنوان
استفاده از درسهای یاد شده از عفونت سیتومگالوویروس در بیماران پیوند به منظور طراحی واکسن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• Immunological variables that correlate with virus suppression have been identified.
• Studies in transplant patients could facilitate the identification of clinical trial endpoints.
• Emerging omics technologies have potential for identifying high value antigens.

Studies in transplant recipients over the past decade aiming to characterize the immune response to cytomegalovirus (CMV) replication have provided insights that can be used to guide CMV vaccine development. These studies have characterized multiple aspects of the immune response to virus infection in humans, and have identified immunologic variables that correlate with the ability to control virus replication. These findings can be used to guide vaccine development by informing decisions regarding antigen selection and the type of immune response that must be elicited by these antigens to promote protective immunity. In addition, these studies have provided information that could aid in the identification of immunologic endpoints in vaccine clinical trials, thus facilitating their design and implementation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 4, April 2016, Pages 674–681
نویسندگان
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