کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2079893 1079901 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human microbial metabolites as a source of new drugs
ترجمه فارسی عنوان
متابولیت های میکروبی انسان به عنوان یک منبع از داروهای جدید
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• Bacterial metabolism of high fiber foods has proven benefits for human health.
• Gut microbiota produce metabolites that interact with the human immune system.
• There is new knowledge about which metabolites are ligands for human receptors.
• Thus knowledge about host–metabolite interactions could reveal novel drug classes.

Crosstalk between the microbiome and the human host is mediated by specific ligand–receptor interactions involving microbially generated metabolites that can be either agonists or antagonists of human proteins. The evolved co-compatibility of gut microbiota with human systems points to a potentially rich area for discovering new drug-like molecules that are both highly specific modulators of human pathways and derisked for adverse effects. In this review, we discuss the rapidly growing research into the role of microbial metabolites in human health and suggest potential strategies for developing these molecules into therapeutic agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 4, April 2016, Pages 692–698
نویسندگان
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