Commercially bioavailable proprietary technologies and their marketed products

• Bioavailability enhancing technologies are explored.
• Surface-modified nanocrystals are one of the most successful approaches.
• Surface-modified cyclodextrin complexes are recent development.
• Advanced carriers for solid dispersion are highlighted.

In this review, we discuss the methodologies and platform technologies for enhancing the oral bioavailability of poorly soluble drugs. We also highlight the mechanisms of formulation technologies for improving desired physicochemical attributes of active substances. We focus on various commercial technologies, along with marketed products, and identify proprietary technologies protected by patents. We also discuss nonpropriety technologies, such as mesoporous silica, cyclodextrin complexation and solid dispersions. In addition, we highlight the factors affecting drug absorption and/or bioavailability, the methodologies available to prepare bioavailability-enhanced products, stability issues and examples of technology implementation.

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