کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2080565 1545140 2012 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MRI as a tool for evaluation of oral controlled release dosage forms
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
MRI as a tool for evaluation of oral controlled release dosage forms
چکیده انگلیسی

The magnetic resonance imaging (MRI) studies of controlled-release (CR) dosage forms can be roughly divided into two groups. The first comprises studies performed in static conditions (small solvent volumes and ambient temperature). Such studies have provided insight into molecular phenomena in hydrating polymeric matrices. The second group covers research performed in dynamic conditions (medium flow or stirring) related to drug dissolution. An important issue is supplementation of the MRI results with data obtained by complementary techniques, such as X-ray microtomography (μCT). As we discuss here, an understanding of the mechanism underlying the release of the drug from the dosage form will lead to the development of detailed, molecularly defined, CR dosage forms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 17, Issues 3–4, February 2012, Pages 110–123
نویسندگان
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