کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2081169 1545209 2006 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibacterial drug discovery and structure-based design
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Antibacterial drug discovery and structure-based design
چکیده انگلیسی

Bacterial resistance continues to develop and pose a significant threat, both in hospitals and, more recently, in the community. A focus on other therapeutic areas by the larger pharmaceutical companies has left a shortfall in the pipeline of novel antibacterials. Recently, many new structures have been studied by structure–genomics initiatives, delivering a wealth of targets to consider. Using the tools of structure-based design, antibacterial discovery must exploit these targets to accelerate the process of drug discovery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 11, Issues 9–10, May 2006, Pages 391–404
نویسندگان
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