کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2081252 1545213 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
چکیده انگلیسی

The use of RNA interference (RNAi) is spreading rapidly to nearly every aspect of biomedical research. The gene silencing capability of RNAi is being used to study individual gene's biological function and role in biochemical pathways. However, the efficacy of RNAi depends upon efficient delivery of the intermediates of RNAi, short interfering RNA (siRNA) and short hairpin RNA (shRNA) oligonucleotides. The delivery challenge is even greater when the aim is to inhibit the expression of target genes in animal models. Although i n vivo delivery of siRNA is complicated and challenging, recent results are encouraging. In this review, the latest developments of in vivo delivery of siRNA and the crucial issues related to this effort are addressed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 11, Issues 1–2, January 2006, Pages 67–73
نویسندگان
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