کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2081397 1545208 2006 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
I want a new drug: G-protein-coupled receptors in drug development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
I want a new drug: G-protein-coupled receptors in drug development
چکیده انگلیسی

Huey Lewis and the News summed it up nicely in their 1980s hit record: ‘I want a new drug, one that won’t make me sick, one that won’t make me crash my car, or make me feel three feet thick’.The song could be an anthem for drug discovery in the pharmaceutical industry. We all want new and better drugs with fewer side effects, which are effective for combating the major diseases of our time: cancer, heart disease, obesity and autoimmune diseases. How do we get these new drugs? There are currently some new ideas in drug discovery, centered on that staple diet of the pharmaceutical industry, the G-protein-coupled receptor (GPCR) superfamily. In silico methods, employing receptor-based modeling, offer a more rational approach in the design of drugs targeting GPCRs. These approaches can be used to understand receptor selectivity and species specificity of drugs that interact with GPCRs. In addition, there are various novel approaches, such as the design and potential utility of drugs that target more than one GPCR (‘dual specificity’ drugs).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 11, Issues 11–12, June 2006, Pages 481–493
نویسندگان
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