SIGIRR, a negative regulator of colon tumorigenesis

Inappropriate activation of the Toll-IL-1R (TLR-IL-1R) signaling by commensal bacteria contributes to the pathogenesis of inflammatory bowel diseases and colitis-associated cancer. Recent studies have identified Single Immunoglobulin IL-1 Receptor Related molecule (SIGIRR) as a negative regulator of TLR-IL-1R signaling. It dampens intestinal inflammation and tumorigenesis in the colon. In this review, we will discuss the role of SIGIRR in different cell types and the mechanisms underlying its tumor suppressor function.