The role of phospholipase A2-derived mediators in obesity

Obesity has become an epidemic and its prevalence is increasing exponentially. A great deal of focus has been given to understanding the molecular processes that regulate obesity. The characterization of phospholipase A2s, especially adipose-specific PLA2, has lead to a proposed role of their downstream products in the progression of obesity and obesity related disorders. This review summarizes recent developments in the role of PLA2 and their downstream effects in the development of metabolic disorders.