Refilling intracellular calcium stores

Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part responsible for orchestrating these movements for the normal functioning of the cardiomyocyte. Alterations of SR regulatory proteins in failing hearts lead to abnormal Ca2+ homeostasis and consequently to a deficient contractile state. This review focuses on the roles of SR Ca2+ regulators in disease states and novel strategies for therapeutic targeting of these pathways.