New aspects of the pathogenesis of rosacea

Rosacea is a chronic, progressive skin disorder affecting primarily the convexities of the central face. Various factors have been suspected of contributing to its pathogenesis including vasculature changes, chronic excessive light exposure, matrix degeneration, emotional stress and hormonal influence. Histological findings present strong evidence of an initial actinic lymphatic vasculopathy. A role of neuropeptides in combination with ultraviolet light-induced skin changes must be considered in the development of rosacea.

Section editor:Michael Roberts – School of Medicine, University of Queensland, Australia