Reaping the benefits of renal protective lipid autacoids

A key feature in the pathophysiology of acute renal injury and glomerulonephritis is exacerbated or non-resolving inflammation. A rapidly evolving field has identified lipoxins and novel ω-3 lipid autacoids as important mediators of inflammatory resolution. These renal lipid autacoid circuits counterbalance proinflammatory cascades, are antifibrotic and maintain renal function. Therapeutic or genetic amplification of protective lipid autacoid circuits heralds a new strategy to halt progressive renal disease and acute renal injury.

Section editor:Michael S. Goligorsky – Renal Research Institute, New York Medical College, Valhalla, NY, USA