Strange bedfellows: biologists and mathematical modelers tie the knot on cardiomyocyte calcium homeostasis

The past several decades of experimental investigation have revealed a rich complexity of cardiomyocyte Ca2+ dynamics. Integrating and decomposing these complex data now increasingly relies on mathematical modeling approaches. In reviewing the evolution and contributions of these cardiomyocyte models, we emphasize the importance of data-driven model parameterization, with iterative data exchange between experimentalists and modelers leading to novel generation of hypotheses.