Models of G-protein-coupled receptor-dependent cardiovascular inflammation

Inflammation is a protective response against invading pathogens and tissue injury, but excessive or dysregulated inflammation underlies many diseases. G-protein-coupled receptors (GPCRs) have long been recognized as important players in the inflammatory response. Recent studies using new in vitro and animal models and new imaging approaches have revealed previously unknown functions of GPCRs. In this review, we summarize recent advances in the many roles of GPCRs and their hierarchical or converging signaling circuitry in the initiation and resolution of inflammation underlying cardiovascular diseases.