Osteoporosis – fracture healing and osseointegration

Osteoporosis is a highly relevant disease and associated with an increased risk of fragility fracture. Also, in patients with osteoporotic condition, unfavorable osseointegration of bone implants remains an issue of concern. Consequently, research in biomaterials is focusing on the therapeutic potential of locally released bioactive, anti-osteoporotic and anabolic drug-loaded implant coatings for osseointegration in osteoporotic conditions. For evaluation of the preclinical efficacy of drug-loaded implant coatings, various experimental models are available that focus on osseointegration and fracture healing in osteoporotic conditions. In view of this, the present review aims to highlight the biological effect of bioactive and pharmacological surface coatings on bone healing and osseointegration of bone implants in osteoporotic bone conditions using in vivo preclinical animal models.