A macaque model for pulmonary hypertension associated with HIV: Part III: Large animal models of pulmonary hypertension and pulmonary embolism for drug discovery today: disease models

Pulmonary arterial hypertension (PAH) is more frequent in chronically HIV-infected patients. There is no animal model to study PAH associated with HIV. Non-human primates infected with SIV (simian homolog of HIV), or with chimeric virions (SIV/HIV, or SHIV), closely recapitulate HIV infection, immunodeficiency, and pulmonary arteriopathy seen in humans with PAH. Here we discuss the pros, cons, and promises in the emerging field focused on long-term complications of HIV infection.