Nervous system cancer models: Medulloblastoma

Medulloblastoma (MB) is the most common childhood malignancy of the central nervous system. In vitro models of the disease have provided insights into the signals necessary for tumorigenesis and identified potential targets for therapeutic intervention. In vivo models induce in situ tumor formation, which more accurately recapitulates the genetic events in human tumors. This review discusses the most recent models and progress made towards developing these models for preclinical studies.

Section editors:Nikolina Vlatovic – University of Liverpool, Liverpool, UKMark T. Boyd – University of Liverpool, Liverpool, UK