Peptide scalpels for site-specific dissection of the DNA–protein interface

Current review highlights emerging strategies for the design of DNA-binding peptides and crosslinking techniques capable of interference at the DNA–protein interface with emphasis on bottom-up organic synthesis. Despite the obvious fundamental character, these inquiries could ultimately result in interesting biomedical applications as designed genome interfering agents or diagnostics. Recent awareness of the potential of these larger peptidomimetic constructs has risen within the medicinal society.

Section editor:Ming-Qiang Zhang – Zhang-Jiang High-Tech Park, Pudong New District, Shanghai, China