کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2082610 1080323 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of physical based methods screening and their delivery of better quality hits
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
The impact of physical based methods screening and their delivery of better quality hits
چکیده انگلیسی

The routine application of high-throughput screening (HTS) of compound files has shifted the bottleneck in target-based drug discovery from hit identification to hit qualification because not all hit molecules have the potential to become leads and drug candidates. Biophysical, label-free detection techniques are generic, direct and information-rich, and there is a growing interest in applying these during hit qualification. Some techniques have seen a rapid development toward enhanced sensitivity and throughput and their application to primary screening is within reach.

Section editors:Phil Gribbon – European ScreeningPort, Hamburg, GermanyKelvin Lam – Harvard University, Cambridge, MA, USA

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today: Technologies - Volume 5, Issue 1, Spring 2008, Pages e15–e22
نویسندگان
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