کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2082610 | 1080323 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The impact of physical based methods screening and their delivery of better quality hits
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
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چکیده انگلیسی
The routine application of high-throughput screening (HTS) of compound files has shifted the bottleneck in target-based drug discovery from hit identification to hit qualification because not all hit molecules have the potential to become leads and drug candidates. Biophysical, label-free detection techniques are generic, direct and information-rich, and there is a growing interest in applying these during hit qualification. Some techniques have seen a rapid development toward enhanced sensitivity and throughput and their application to primary screening is within reach.
Section editors:Phil Gribbon – European ScreeningPort, Hamburg, GermanyKelvin Lam – Harvard University, Cambridge, MA, USA
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today: Technologies - Volume 5, Issue 1, Spring 2008, Pages e15–e22
Journal: Drug Discovery Today: Technologies - Volume 5, Issue 1, Spring 2008, Pages e15–e22
نویسندگان
Jan Kahmann, Dirk Winkler, Thomas Hesterkamp,