Computational design of protein therapeutics

Computation is increasingly used to guide protein therapeutic designs. Some of the potential applications for computational, structure-based protein design include antibody affinity maturation, modulation of protein–protein interaction, stability improvement and minimization of protein aggregation. The versatility of a computational approach is that different biophysical properties can be analyzed on a common framework. Developing a coherent strategy to address various protein engineering objectives will promote synergy and exploration. Advances in computational structural analysis will thus have a transformative impact on how protein therapeutics are engineered in the future.

Section editors:Marco van de Weert and Eva Horn Moeller – Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark