New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery

In the postgenomic era, computer-aided drug design (CADD) has considerably extended its range of applications, spanning almost all stages in the drug discovery pipeline, from target identification to lead discovery, from lead optimization to preclinical or clinical trials. Two new technologies of CADD associated with target identification and new chemical entity discovery will be the focus of this review.

Section editors:Li-he Zhang – School of Pharmaceutical Science, Peking University, Beijing, ChinaKaixian Chen – Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China