The use of affinity sorbents in targeted proteomics

The complexity of most proteomes is too high to obtain a truly comprehensive view of all expressed proteins by any of the current technologies. Prefractionation techniques are thus necessary to dig deeper into the low-abundance region of the proteome. Progress in the application of affinity sorbents to focus on particular protein classes of low abundance, while at the same time adding understanding about their function through the way they interact with the affinity ligands, will be described.

Section editors:Harald John – Bundeswehr, Institute of Pharmacology and Toxicology, Munich, GermanyRainer Bischoff – Centre of Pharmacy, University of Groningen, The Netherlands