Stem cells, immortalized cells and primary cells in ADMET assays

Cell-based assays are beginning to replace traditional absorption, distribution, metabolism, elimination and toxicology (ADMET) models employing subcellular fractions in high throughput drug discovery screening and drug development where drugs are characterized and predictions are formulated to forecast in vivo biological outcomes. Significant and continuing advances in stem cell research, new immortalized cell lines and our enhanced ability to predict outcomes from primary cells have increased the ability to employ cell-based assays to study ADMET properties of new drugs.

Section editors:Charles L. Crespi – BD Biosciences, Woburn, MA, USAKenneth Thummel – University of Washington, Seattle, WA, USA