theraTRACE®: a mechanism unbiased in vivo platform for phenotypic screening and drug repositioning

Drug repositioning is an emerging strategy for filling the innovation gap in the pharmaceutical industry. Successful drug repositioning examples are nearly always explained by observations made in clinical settings or in in vivo therapeutic models. We have established an in vivo phenotypic platform, termed theraTRACE® that systematically evaluates and repositions drugs to new indications. This review article describes examples of drugs found using phenotypic models and the concepts behind the theraTRACE® approach.