کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2083184 1545316 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unsaturated fatty acids lactose esters: cytotoxicity, permeability enhancement and antimicrobial activity
ترجمه فارسی عنوان
اسیدهای چرب اشباع نشده لاکتوز استرها: سمیت سلولی، افزایش نفوذپذیری و فعالیت ضد میکروبی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

Sugar based surfactants conjugated with fatty acid chains are an emerging broad group of highly biocompatible and biodegradable compounds with established and potential future applications in the pharmaceutical, cosmetic and food industries. In this work, we investigated absorption enhancing and antimicrobial properties of disaccharide lactose, monoesterified with unsaturated fatty acids through an enzymatic synthetic approach. After chemical and cytotoxicity characterizations, their permeability enhancing activity was demonstrated using intestinal Caco-2 monolayers through transepithelial electrical resistance (TEER) and permeability studies. The synthesized compounds, namely lactose palmitoleate (URB1076) and lactose nervonate (URB1077), were shown to exhibit antimicrobial activity versus eight pathogenic species belonging to Gram-positive, Gram-negative microorganisms and fungi.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 107, October 2016, Pages 88–96
نویسندگان
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