کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2083474 | 1545350 | 2013 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: In vivo sustained dermal delivery and pharmacokinetics of interferon alpha in biphasic vesicles after topical application In vivo sustained dermal delivery and pharmacokinetics of interferon alpha in biphasic vesicles after topical application](/preview/png/2083474.png)
Biphasic vesicles, a novel nanostructured lipid-based delivery system show potential for topical application of interferon alpha (IFN α) for the treatment of human papillomavirus (HPV) infections (anogenital warts). Dermal delivery of IFN α encapsulated in biphasic vesicles (BPV-IFN α), applied topically to the skin, was characterized in a guinea pig model.BPV-IFN α (1 g, 2 MIU/g) was topically applied either as a single or multiple treatments on the skin of guinea pigs. As a comparison with currently used regimens, IFN α solution was administered intravenously or intradermally. Skin and serum samples were collected over 96 h, IFN α levels were determined by an antiviral assay, and half-life (t1/2) and elimination (k) rates were calculated.Topical BPV-IFN α treatment resulted in maximum skin levels (about 100,000 U/100 cm2) of IFN α within 6 h and maintained for 72–96 h. Clearance from the skin after intradermal injections was initially fast (t1/2 0.62 h, k 1.1179 h−1), followed by a slower steady decrease after 6 h. After intravenous and intradermal administration, IFN α was rapidly cleared from the serum, t1/2 0.75 h, k 0.9271 h−1 and t1/2 1.28 h, k 0.5421 h−1, respectively, whereas after topical application, IFN α levels remained below 100 U/mL. Topical application of BPV- IFN α resulted in sustained delivery of biologically active IFN α locally into skin with minimal systemic exposure.
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Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 84, Issue 3, August 2013, Pages 532–539