کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2083507 1545337 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy
ترجمه فارسی عنوان
پلی یونولین مبتنی بر پلی اورتان پوشش داده شده به عنوان سیستم های تحویل بالقوه دارو برای درمان سرطان هدفمند است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• A highly biocompatible PEGylated squalene-grafted-inulin copolymer was synthesized.
• Polymer coated SPIONs were obtained by spontaneous self-assembling onto magnetite surface.
• Doxorubicin-loaded nanoparticles showed good magnetic targeting and in vitro anticancer activity.

This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnetite surface involving hydrophobic–hydrophobic interactions between the metallic core and the squalene moieties. The system was characterized in terms of hydrodynamic radius, zeta potential, shape and drug loading capacity. On the whole, the stealth-like shell stabilized the suspension in aqueous media, though allowing the release of the doxorubicin loaded in therapeutic range. The cytotoxicity profile on cancer (HCT116) cell line and in vitro drug uptake were evaluated both with and without an external magnetic field used as targeting agent and uptake promoter, displaying that magnetic targeting implies advantageous therapeutic effects, that is amplified drug uptake and increased anticancer activity throughout the tumor mass.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 88, Issue 3, November 2014, Pages 695–705
نویسندگان
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