Comparative release studies of two cationic model drugs from different cellulose nanocrystal derivatives

• CSOS was grafted on oxidized CNC using peptidic coupling reaction.
• ITC was used to gain an understanding into the nature of interactions of a model drugs and CNC derivatives.
• Imipramine hydrochloride (IMI) displayed higher binding to CNC derivatives than procaine hydrochloride (PrHy).

Native cellulose nanocrystal (CNC), oxidized CNC (CNC-OX) and chitosan oligosaccharide grafted CNC (CNC-CSOS) were evaluated as potential drug delivery carriers for two model drug compounds, procaine hydrochloride (PrHy) and imipramine hydrochloride (IMI). The loading of PrHy and IMI was performed at pH 8 and 7, respectively. IMI displayed higher binding to CNC derivatives than PrHy. Drug selective membranes were prepared for each model drug and a drug selective electrode system was used to measure the drug concentration in the filtrate and release medium. Isothermal Titration Calorimetry (ITC) was used to elucidate the types of interactions between model drugs and CNC and its derivatives. The complexation between model drugs and CNC derivatives was confirmed by zeta potential and transmittance measurements. The binding and release of these drugs correlated with the nature and types of interactions that exist between the CNC and drug molecules.

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