کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2083679 1545356 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study of drug release and tablet characteristics of silicone adhesive matrix tablets
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Study of drug release and tablet characteristics of silicone adhesive matrix tablets
چکیده انگلیسی

Matrix tablets of a model drug acetaminophen (APAP) were prepared using a highly compressible low glass transition temperature (Tg) polymer silicone pressure sensitive adhesive (PSA) at various binary mixtures of silicone PSA/APAP ratios. Matrix tablets of a rigid high Tg matrix forming polymer ethyl cellulose (EC) were the reference for comparison. Drug release study was carried out using USP Apparatus 1 (basket), and the relationship between the release kinetic parameters of APAP and polymer/APAP ratio was determined to estimate the excipient percolation threshold. The critical points attributed to both silicone PSA and EC tablet percolation thresholds were found to be between 2.5% and 5% w/w. For silicone PSA tablets, satisfactory mechanical properties were obtained above the polymer percolation threshold; no cracking or chipping of the tablet was observed above this threshold. Rigid EC APAP tablets showed low tensile strength and high friability. These results suggest that silicone PSA could eliminate issues related to drug compressibility in the formulation of directly compressed oral controlled release tablets of poorly compressible drug powder such as APAP. No routinely used excipients such as binders, granulating agents, glidants, or lubricants were required for making an acceptable tablet matrix of APAP using silicone PSA.

Polymer rigidity affects the tensile strength and porosity of the controlled release matrix tablets formed using the polymers.Figure optionsDownload high-quality image (90 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 82, Issue 3, November 2012, Pages 518–525
نویسندگان
, ,