کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2084269 | 1545386 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Electroosmotic flow as a result of buccal iontophoresis – Buccal mucosa properties Electroosmotic flow as a result of buccal iontophoresis – Buccal mucosa properties](/preview/png/2084269.png)
The objective of this study was to investigate and to better understand the properties of buccal mucosa as a semipermeable membrane and a portal for drug administration by iontophoretic and electroosmotic means. In vitro experiments showed that buccal mucosa at the pH of about 7.4 behaved as a cation-exchange membrane and non-linear resistor. It had lower resistance and was more permeable for water than a skin. The electroosmotic volume flow through mucosa depended on current density, mucosa resistance and electrolyte concentration. Sodium dodecyl sulfate (in concentration range 0.001–0.005 mol L−1) and urea (in concentration range 0.42–1.67 mol L−1) did not promote a water transfer through buccal mucosa, however, both substances enhanced flow through the skin.
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 72, Issue 3, August 2009, Pages 595–599