کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2084292 1545376 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SRMS142-based solid lipid microparticles: Application in oral delivery of glibenclamide to diabetic rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
SRMS142-based solid lipid microparticles: Application in oral delivery of glibenclamide to diabetic rats
چکیده انگلیسی

P90Gylation refers to the modification of lipid molecules by one or more phospholipid chains. Phospholipon® 90G (P90G) contains about 94.0% of phosphatidylcholine stabilized with 0.1% ascorbyl palmitate and is a safe (GRAS) FDA-approved parenteral excipient with wide applications in drug delivery. P90Gylated-Softisan® 142 conjugate, otherwise referred to as (SRMS142), has numerous advantages: wetting, solubilization, drug stabilization, emulsification, and modified release. Here, we report an evaluation of solid lipid microparticles (SLMs) formulated from SRMS142 systems as an alternative carrier system for oral glibenclamide administration in diabetic rats. The result of our findings showed that SRMS142 generated an imperfect matrix with numerous spaces that accommodated glibenclamide in a concentration-dependent manner up to 60.58%. The blood glucose–lowering effect of the SLMs was higher than that of a commercial sample.

Enhanced solubility and bioavailability of glibenclamide from SLMs based on P90Gylated-Softisan® 142 matrices (SRMS142).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 76, Issue 1, September 2010, Pages 68–74
نویسندگان
, , , ,